Evidence map›Paper›PMID 42234791›Full record

ArticleOrganic letters2026

Unactivated Photoredox C-H Amination with Diazirines: Access to Acyldiaziridines.

Daria V Galaktionova, Vishala Maharaj, Justin M Lopchuk

Abstract read
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daria V GalaktionovaDrug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, United States.
Vishala MaharajDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Justin M LopchukDrug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, United States.ORCID 0000-0002-6910-6132

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
New reagents for C-C and C-N bond formationR35GM142577 · NIGMS · H. LEE MOFFITT CANCER CTR & RES INST · PI LOPCHUK, JUSTIN MATTHEW · 2021 to 2025
$2.2M
NCI NIH HHS P30 CA076292NIGMS NIH HHS R35 GM142577
6 · The paper itself

Abstract

A metal-free, photoinduced amination of unactivated C-H bonds from abundant, simple alkanes with diazirines is reported. The transformation provides diversifiable diaziridine products (40 examples) in up to 95% yields. The conditions are suitable for four different classes of C-H bonds, including aldehydes, which results in the formation of previously unavailable acyldiaziridines. This class of molecules is shown to consist of versatile precursors that are easily converted into amides, hydrazides, acyl hydrazones, and heterocycles.

Identifiers

PMID42234791
PMCPMC13352326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.