Evidence map›Paper›PMID 42234737›Full record

ArticleScience advances2026

Transposons drove the evolution of a male sex-determining gene from a female gene with deep introgression across cichlids.

Le Wang, Fei Sun, Zituo Yang, May Lee, Joey Wong, Shadame Yeo, Yanfei Wen, Axel Meyer, Francesc Piferrer, Manfred Schartl and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Le WangTemasek Life Sciences Laboratory, Singapore 117604, Singapore.ORCID 0000-0002-3363-5753
Fei SunTemasek Life Sciences Laboratory, Singapore 117604, Singapore.ORCID 0000-0002-9998-4331
Zituo YangTemasek Life Sciences Laboratory, Singapore 117604, Singapore.ORCID 0000-0003-2206-0445
May LeeTemasek Life Sciences Laboratory, Singapore 117604, Singapore.ORCID 0000-0001-9188-3627
Joey WongTemasek Life Sciences Laboratory, Singapore 117604, Singapore.ORCID 0000-0001-7858-3267
Shadame YeoTemasek Life Sciences Laboratory, Singapore 117604, Singapore.ORCID 0000-0003-4717-377X
Yanfei WenTemasek Life Sciences Laboratory, Singapore 117604, Singapore.ORCID 0000-0002-7852-4133
Axel MeyerDepartment of Biology, University of Konstanz, 78457 Konstanz, Germany.ORCID 0000-0002-0888-8193
Francesc PiferrerInstitute of Marine Sciences (ICM), Spanish National Research Council (CSIC), 08003 Barcelona, Spain.ORCID 0000-0003-0903-4736
Manfred SchartlInstitute of Pathology, University of Wuerzburg, 97074 Wuerzburg, Germany.ORCID 0000-0001-9882-5948
Gen Hua YueTemasek Life Sciences Laboratory, Singapore 117604, Singapore.ORCID 0000-0002-3537-2248

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex-determination mechanisms and their master regulators are diverse among vertebrates. Components of downstream regulatory pathways can sometimes be co-opted as new upstream triggers. Here, we report a notable finding of cross-pathway recruitment: A gene from the female differentiation cascade was repurposed as a male master sex-determining (MSD) gene. We identify

Indexed as

CichlidsDNA Transposable ElementsEvolution, MolecularSex Determination ProcessesAnimalsFemaleMalePhylogenyPromoter Regions, GeneticSex DifferentiationDNA Transposable Elements

Identifiers

PMID42234737
PMCPMC13232571

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.