Evidence map›Paper›PMID 42234734›Full record

ArticleScience advances2026

Sol-gel interconvertible 62-component dodecahedra assembled via amide-π-assisted anion-coordination nanoarchitectonics.

Wen-Zheng Fu, Zhu Zhuo, Zi-Ang Nan, Wei Wang, Jun-Rui Liu, Qing Li, Lu-Yao Liu, Ting Chen, Yu-Long Zhang, Zhong-Qun Tian and 3 more

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Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Wen-Zheng FuState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.ORCID 0009-0000-8638-3193
Zhu ZhuoState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.ORCID 0000-0002-9131-3883
Zi-Ang NanState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.ORCID 0000-0003-0635-9789
Wei WangState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.ORCID 0000-0003-3178-236X
Jun-Rui LiuState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.
Qing LiState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.
Lu-Yao LiuState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.ORCID 0009-0006-3644-5572
Ting ChenState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.ORCID 0009-0006-8286-9587
Yu-Long ZhangState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.ORCID 0009-0007-2582-7978
Zhong-Qun TianState Key Laboratory of Physical Chemistry of Solid Surfaces, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, iChEM, College of Chemistry and Chemical Engineering, College of Energy, College of Materials, College of Physical Science and Technology, Xiamen University, Xiamen, China.ORCID 0000-0002-9775-8189
Zhihao LiSouth China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, South China University of Technology, Guangzhou 510640, China.
Mao-Chun HongState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.
You-Gui HuangState Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.ORCID 0000-0001-9962-3723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses achieve remarkable complexity through the self-assembly of protein subunits, yet mimicking such processes synthetically has remained a grand challenge. While a 144-component metal-organic cage has been obtained, the maximum component count for known supramolecular assemblies of weak noncovalent forces is only 20. Here, we report a 62-component supramolecular cage assembled via a bioinspired strategy. By combining anion coordination with amide-π interactions, we construct a 62-component discrete dodecahedral cage structurally analogous to the dengue virus. This synthetic architecture, comprising three distinct molecular species held together via 60 H-bonds and 30 sets of amide-π interactions, demonstrates excellent stability in solution and exhibits multiple solid structural polymorphs. A reversible sol-gel transition is achieved by a mixture of the dodecahedra in acetylacetone (acac), which is driven by the host-guest-mediated higher-order assembly. These findings establish a previously unidentified paradigm for constructing multicomponent supramolecular cages, opening avenues for developing bioinspired molecular nanocontainers and providing a foundation for diverse nanotechnological applications.

Identifiers

PMID42234734
PMCPMC13232590

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.