Evidence map›Paper›PMID 42234524›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Extended sequence context shapes mutational bias in

Matthew J Jago, Rowan Green, Maisie R Czernuszka, Stepan Denisov, Rok Krašovec, Christopher G Knight, Mato Lagator

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Extended sequence context shapes mutational bias inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew J JagoDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.ORCID 0009-0003-9511-2020
Rowan GreenDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.ORCID 0000-0002-2147-9087
Maisie R CzernuszkaDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.ORCID 0009-0004-6997-0037
Stepan DenisovDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.ORCID 0000-0001-6465-3818
Rok KrašovecDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.ORCID 0000-0003-4490-5605
Christopher G KnightDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.ORCID 0000-0001-9815-4267
Mato LagatorDivision of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.ORCID 0000-0001-7847-3594

Funding

UKRI | Engineering and Physical Sciences Research Council (SRC) EP/S022856/1Wellcome Trust (WT) 216779/Z/19/Z
6 · The paper itself

Abstract

Understanding how sequence context influences the likelihood of mutation at a given genomic locus is critical for deciphering evolutionary processes. It is well established that the immediately adjacent bases influence mutation rates, but the role of more distal bases remains poorly understood. Here, we analyze over 100,000 mutations from 32

Indexed as

Escherichia coliMutationBase SequenceDNA, BacterialDNA Mismatch RepairDNA RepairDNA ReplicationMutation RateDNA, BacterialDNA proofreadingmismatch repairmutational biasmutational hotspotssequence context

Identifiers

PMID42234524
PMCPMC13250602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.