Evidence map›Paper›PMID 42234520›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Host methylglyoxal activates the

Andrea Anaya-Sanchez, Preethi T Ragunathan, Angela Hung, Andrew J Van Alst, Mariya Lobanovska, Sarah A Stanley, Daniel A Portnoy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea Anaya-SanchezMicrobiology Graduate Group, University of California, Berkeley, CA 94720.
Preethi T RagunathanDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Angela HungDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Andrew J Van AlstDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Mariya LobanovskaDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-3513-301X
Sarah A StanleyDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-4182-9048
Daniel A PortnoyMicrobiology Graduate Group, University of California, Berkeley, CA 94720.ORCID 0000-0003-1218-2799

Funding

The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI PORTNOY, DANIEL A · 2004 to 2025
$45.5M
Listeria Hemolysis and Escape From a VacuoleR01AI027655 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DANIEL A PORTNOY · 1993 to 2026
$10.1M
NIAID NIH HHS P01 AI063302NIAID NIH HHS R01 AI027655
6 · The paper itself

Abstract

Methylglyoxal is a reactive aldehyde produced by macrophages as part of their antimicrobial innate immune arsenal. Our prior work showed that

Indexed as

Listeria monocytogenesListeriosisPhagocytesPyruvaldehydeAnimalsBacterial ProteinsGlutathioneHost-Pathogen InteractionsLactoylglutathione LyaseMacrophagesMiceMutationPeptide Termination FactorsVirulenceBacterial ProteinsGlutathioneLactoylglutathione LyasePeptide Termination FactorsPrfA protein, Listeria monocytogenesPyruvaldehydeactinbacteriaintracellular pathogensmacrophagesmutations and DNA repair

Identifiers

PMID42234520
PMCPMC13250588

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.