Evidence map›Paper›PMID 42234519›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity.

Larissa Ernst, Cornelia Gätgens, Bente Rackow, Nadiia Pozhydaieva, Elyès Gaaloul, Aileen Krüger, Johannes Seiffarth, Michelle Bund, Vivien Joisten-Rosenthal, Dietrich Kohlheyer and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Larissa ErnstInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich 54425, Germany.ORCID 0000-0001-8431-8216
Cornelia GätgensInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich 54425, Germany.
Bente RackowInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich 54425, Germany.ORCID 0009-0004-8703-0823
Nadiia PozhydaievaMax Planck Institute for Terrestrial Microbiology, Marburg 35037, Germany.ORCID 0000-0003-2468-4235
Elyès GaaloulMax Planck Institute for Terrestrial Microbiology, Marburg 35037, Germany.ORCID 0009-0000-0101-0356
Aileen KrügerInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich 54425, Germany.
Johannes SeiffarthInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich 54425, Germany.
Michelle BundInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich 54425, Germany.ORCID 0000-0002-3844-7428
Vivien Joisten-RosenthalFaculty of Mathematics and Natural Sciences, Institute for Biological Data Science, Heinrich-Heine-University Düsseldorf, Düsseldorf 40225, Germany.ORCID 0009-0000-0645-6891
Dietrich KohlheyerInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich 54425, Germany.ORCID 0000-0001-6215-1857
Björn UsadelFaculty of Mathematics and Natural Sciences, Institute for Biological Data Science, Heinrich-Heine-University Düsseldorf, Düsseldorf 40225, Germany.
Alexander HarmsDepartment of Health Sciences and Technology, Institute of Food, Nutrition, and Health, ETH Zürich, Zürich 8092, Switzerland.ORCID 0000-0003-2106-1286
Katharina HöferMax Planck Institute for Terrestrial Microbiology, Marburg 35037, Germany.
Julia FrunzkeInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich 54425, Germany.ORCID 0000-0001-6209-7950

Funding

Deutsche Forschungsgemeinschaft (DFG) 458090666Deutsche Forschungsgemeinschaft (DFG) 464434020Deutsche Forschungsgemeinschaft (DFG) 464500427
6 · The paper itself

Abstract

Bacteria deploy diverse antiphage defense systems, including small bioactive molecules providing protection at the multicellular level. DNA-intercalating anthracyclines, such as daunorubicin, exhibit broad antiphage activity, but the underlying mechanism has remained elusive. Here, we systematically screened the

Indexed as

BacteriophagesDaunorubicinEscherichia coliDNA, ViralDaunorubicinDNA, Viralbacterial immunitybacteriophagedaunorubicinphage defenseT5

Identifiers

PMID42234519
PMCPMC13250531

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.