ArticlePulmonary therapy2026
Impact of Single-Inhaler Triple Therapy FF/UMEC/VI on Disease Stability in COPD: A Real-World 12-Month Analysis.
Article in Pulmonary therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- COPD Stability and Asthma Remission: Different Words for the Same Therapeutic Ambition?Biomedicines · 2026Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSingle-inhaler triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) is recommended for patients with chronic obstructive pulmonary disease (COPD) who remain symptomatic or experience exacerbations despite dual bronchodilation. However, real-world evidence on its ability to achieve multidimensional "disease stability", integrating symptoms, lung function, and exacerbation outcomes, remains limited. The aim of our study was therefore to evaluate, in a real-world cohort of exacerbating patients with COPD, the effects of once-daily FF/UMEC/VI on lung function, respiratory symptoms, health status, and exacerbation rates over 12 months.
methodsThis retrospective single-center study included 86 adults with COPD treated with FF/UMEC/VI 92/55/22 µg at the Respiratory Unit of "Magna Graecia" University Hospital (Catanzaro, Italy). Lung function tests (forced expiratory volume in the first second, FEV
resultsEighty-six patients were included (24 women, 28%; 62 men, 72%), with a mean age of 72.29 ± 9.20 years and a median BMI of 30 (26.00-36.50) kg/m
conclusionsIn this real-world cohort of exacerbating patients with COPD, once-daily single-inhaler FF/UMEC/VI was associated with improved lung function, reduced hyperinflation, better symptom control, enhanced quality of life, and a significant reduction in exacerbation frequency. These findings suggest that FF/UMEC/VI may be a useful therapeutic option for supporting multidimensional disease stability in high-risk patients with COPD, although prospective controlled studies are needed to confirm these observations.
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