ArticleBiomechanics and modeling in mechanobiology2026
Influence of substrate thickness on cell-perceived stiffness: a computational study.
Article in Biomechanics and modeling in mechanobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cell culturing on soft substrates has become a widely applied method towards mimicking the compliant mechanical environment of cells in vivo, and substrate stiffness was shown to influence cell behavior. The cell-perceived stiffness, however, does not only depend on the modulus of the substrate material, but also on its thickness. In the present work, we propose an in silico approach to quantify the effect of substrate thickness on cell-perceived substrate stiffness. We coupled a discrete network representation of the cellular cytoskeleton including subcellular cell-substrate connections, i.e. focal adhesions (FA), with a continuum model of the substrate, and simulated the contraction of individual cells and cell patches. The results indicate that for substrates of heights larger than a multiple of the FA size (i.e. in the range of 5-10
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