ArticleInflammation2026
B10 Adoptive Transfer Ameliorates Inflammation and Bone Loss in Experimental Periodontitis Through Promoting Macrophage-Mediated Pro-Resolving Functions.
Article in Inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Immune cell-cell interaction plays a critical role in the regulation of inflammatory responses. IL-10-expressing regulatory B cells (B10) alleviate the periodontal inflammation and bone loss by secreting IL-10, which can stimulate pro-resolving macrophage differentiation. However, little is known about the dynamic B10-macrophage interaction and the specific B10-induced pro-resolving functions in vivo in periodontitis. This study aimed to determine the dynamic local infiltration of B10 and macrophages, and the B10-induced macrophage differentiation and functions in experimental periodontitis. B10 were adoptively transferred via tail vein injection in a mouse model of experimental periodontitis. In some experiments, macrophages were depleted by intraperitoneal injection of clodronate liposomes. Dynamic gingival infiltration of B10 and macrophages were evaluated by in vivo imaging system (IVIS). The level of bone loss was evaluated by Micro-CT and TRAP staining. Cytokine productions, macrophage efferocytosis and autophagy were assessed by immunohistochemical / immunofluorescence analysis. Production of specialized pro-resolving mediators (SPMs) was detected by LC-MS/MS. B10 adoptive transfer inhibited alveolar bone resorption and osteoclast differentiation. B10 adoptive transfer promoted the number of pro-resolving macrophages compared with the control groups. A significant increase in IL-10, Arg-1, and YM-1, ATG5⁺, LC3B⁺, CD68⁺LC3B⁺, CD68
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