Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Photobiomodulation therapy for oral mucositis: clinical experience from a supportive care program at the Indian Institute of Head and Neck Oncology.
Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPhotobiomodulation (PBM), the therapeutic use of non-ionizing red to near-infrared light, has emerged as a safe, non-invasive, evidence-based modality for managing oral mucositis (OM) in oncology.
objectiveTo evaluate the feasibility and therapeutic outcomes of photobiomodulation therapy (PBMT) within a structured multidisciplinary supportive care pathway at a charitable oncology center in India, specifically comparing outcomes against a historical control cohort.
methodsThis observational cohort study included 132 patients with head and neck squamous cell carcinoma undergoing curative or adjuvant radiotherapy/chemoradiotherapy. PBMT was initiated at first clinical evidence of mucositis (WHO grade ≥ 1). Baseline for analysis was defined as the time of PBMT initiation. Outcomes were compared with a matched historical control cohort (n = 100) treated prior to PBMT implementation.
resultsSevere mucositis (grades 3-4) in the PBMT cohort declined from 57% at baseline (time of PBMT initiation) to 2% at 8 weeks. The PBMT cohort demonstrated significantly superior outcomes compared to historical controls, including lower peak mucositis grades (2.9 vs. 3.5; p < 0.01), shorter duration of severe mucositis (1.2 vs. 3.4 weeks; p < 0.01), and reduced opioid reliance (57% vs. 85%; p < 0.01).
conclusionPBMT was associated with improved mucositis severity and pain outcomes within a structured supportive care framework in head and neck cancer patients in tertiary cancer center. Compared with historical controls, PBMT was associated with lower peak mucositis grades shorter duration of severe mucositis and reduced opioid use. This findings suggest that PBMT may represent a practical adjunct in resource constrain oncology settings.
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