Multiscale mechano-biological characterization of necrotic, sclerotic, and healthy zones in femoral head osteonecrosis: linking viscoelastic heterogeneity to mechanical failure.

Ajeesh M Kurup, Rajesh Kumar Bhushan, Saroj Kumar, Amit Kumar, Naveen Kumar, Ramesh Kumar Sen, Navin Kumar

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Article in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Ajeesh M KurupDepartment of Mechanical Engineering, National Institute of Technology Manipur, Imphal, 795004, India. ajeeshmkurup@nitmanipur.ac.in.ORCID http://orcid.org/0000-0002-1883-9061

Rajesh Kumar BhushanDepartment of Mechanical Engineering, National Institute of Technology Manipur, Imphal, 795004, India.

Saroj KumarDepartment of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, 140001, India.

Amit KumarDepartment of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, 140001, India.

Naveen KumarDepartment of Orthopaedic Surgery, Institute of Orthopaedic Surgery, Max Superspeciality Hospital, Mohali, 160055, India.

Ramesh Kumar SenDepartment of Orthopaedic Surgery, Institute of Orthopaedic Surgery, Max Superspeciality Hospital, Mohali, 160055, India.

Navin KumarDepartment of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, 140001, India.

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6 · The paper itself

Abstract

Osteonecrosis of the femoral head (ONFH) is a progressive disorder characterized by regional trabecular bone deterioration that ultimately results in collapse. While elastic property changes in diseased bones are well documented, the contribution of region-specific viscoelastic behavior and its relationship to multiscale microarchitecture and composition remain insufficiently defined. Eighteen femoral heads (mean age: 40.8 ± 7.1 years; 15 males, 3 females; diagnosis: Ficat Stage III/IV) were retrieved during total hip arthroplasty. Patient-matched trabecular cores were harvested from three distinct zones: necrotic (NCZ), sclerotic (SCZ), and healthy (HZ). Bone quality was evaluated using micro-CT, uniaxial compression, nanoindentation, FTIR, and XRD. Viscoelasticity was characterized via stress relaxation and dynamic mechanical analysis (DMA) tests. The NCZ demonstrated microarchitectural decay (bone volume/total volume reduced by 54.54%, p < 0.001) and lower elastic modulus (reduced by 60.25%, p < 0.001) compared to SCZ. DMA revealed that while the NCZ exhibited the lowest storage modulus (E

Indexed as

Femur HeadFemur Head NecrosisAdultBiomechanical PhenomenaElasticityFemaleHumansMaleMiddle AgedSclerosisStress, MechanicalViscosityX-Ray MicrotomographyBone-microarchitectureDynamic mechanical analysisOsteonecrosisStress relaxationViscoelasticity

Identifiers

PMID42234096

DOI10.1016/j.ijimpeng.2013.12.003

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.