Intraosseous pressure measurement of cystic bone lesions and comparison with normal marrow.

J Rafael T Vicentini, Sina Habibollahi, Ukasha Habib, Connie Y Chang

Abstract readComparative Study

In one paragraph

Article in Skeletal radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J Rafael T VicentiniDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Yawkey 6E, Boston, MA, 02114, USA. jvicentini@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-0838-1659

Sina HabibollahiDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Yawkey 6E, Boston, MA, 02114, USA.

Ukasha HabibDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Yawkey 6E, Boston, MA, 02114, USA.

Connie Y ChangDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Yawkey 6E, Boston, MA, 02114, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo (1) measure intraosseous pressure (IOP) in cystic bone lesions and compare it with pressure values in normal bone marrow from a previous cohort; (2) to investigate the relationship between intralesional and systemic blood pressure. MATERIALS AND

methodsIn this prospective HIPAA-compliant study, patients referred for CT-guided sclerotherapy of cystic bone lesions or CT-guided bone marrow biopsy between November 2020 and February 2022 were consecutively enrolled. IOP was recorded in vivo through the biopsy needle using a closed arterial pressure monitoring system for 5 min. Demographic variables and systemic blood pressure were collected. Continuous and categorical variables were compared using the Student t test and Fisher's exact test, respectively. Pearson correlation was used to assess the relationship between intraosseous and systemic blood pressure. A p value < 0.05 was considered statistically significant.

resultsSeven patients with cystic bone lesions (CBL) and 45 patients with normal marrow histology were included. Participants with CBL were younger than those in the normal marrow group (20 ± 4 vs 55 ± 14 years; p < 0.001) and had lower mean arterial pressure (80 ± 11 vs 93 ± 13 mmHg; p = 0.02). Systolic intraosseous pressures were significantly higher in cystic lesions (90 ± 18 mm Hg vs. 67 ± 23 mm Hg, p = 0.01). There was no significant correlation between systemic blood pressure and intraosseous pressure (all p > 0.35).

conclusionCystic bone lesions demonstrate elevated intraosseous pressures, particularly systolic parameters, compared with normal marrow. Intraosseous pressures appear independent of systemic blood pressure.

Indexed as

Bone CystsBone MarrowTomography, X-Ray ComputedAdultBlood PressureFemaleHumansImage-Guided BiopsyMaleMiddle AgedProspective StudiesSclerotherapyYoung AdultAneurysmal bone cystBone marrowCT-guided biopsyIntraosseous pressureSclerotherapy

Identifiers

PMID42234093

DOI10.1007/s00256-026-05259-3

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.