Deep learning for early detection of Zenker's diverticulum based on swallowing sound analysis.

purposePatients with Zenker's diverticulum (ZD) often suffer from oropharyngeal dysphagia that can go undiagnosed for years. Diagnosis of ZD typically requires specialized centers and videofluoroscopy. Our study aims to create a noninvasive, accessible, sound-based screening tool for healthcare professionals to reduce diagnostic barriers and enable earlier detection of ZD.

methodsWe developed a two-stage deep learning model to detect ZD using cervical auscultation sounds. The first stage identifies swallowing sounds (idle vs. swallow), and the second classifies detected swallows as healthy or pathological (Healthy vs. ZD). We used transfer learning with a pre-trained audio spectrogram transformer (AST) backbone and fine-tuned it for our task. A fivefold cross-validation protocol was applied to evaluate the model's performance. For data collection, we built a portable cervical auscultation device to gather recordings from 23 ZD patients and 27 healthy volunteers.

resultsThe proposed method achieved a patient-level ZD diagnosis accuracy of

conclusionThis study demonstrates, to our knowledge, the first deep learning-based cervical auscultation approach for identifying ZD. The results indicate that auscultation-driven AST-based models can provide clinically meaningful sensitivity and may help to lower diagnostic barriers, enable earlier referral, and ultimately reduce healthcare costs in dysphagia care.