Evidence map›Paper›PMID 42234057›Full record

ArticleJournal of neuro-oncology2026

Radiologic analysis of large vestibular schwannoma position on surgical outcomes.

Hayley A Granberg, Alireza Zonnour, Gabriela S Navarro-Parga, Kenneth Thomas, Michael G Brandel, Krish Suresh, Rick Friedman, Marc Schwartz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hayley A GranbergRocky Vista University College of Osteopathic Medicine, Parker, CO, USA.
Alireza ZonnourDepartment of Otolaryngology, University of California San Diego, San Diego, CA, USA.
Gabriela S Navarro-PargaDepartment of Otolaryngology, University of California San Diego, San Diego, CA, USA.
Kenneth ThomasRocky Vista University College of Osteopathic Medicine, Parker, CO, USA.
Michael G BrandelDepartment of Neurological Surgery, University of California San Diego, San Diego, CA, USA.
Krish SureshDepartment of Otolaryngology, University of California San Diego, San Diego, CA, USA.
Rick FriedmanDepartment of Otolaryngology, University of California San Diego, San Diego, CA, USA. rafriedman@health.ucsd.edu.
Marc SchwartzDepartment of Neurological Surgery, University of California San Diego, San Diego, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLarge vestibular schwannomas (VS) often compress the brainstem and differ in their relation to the internal auditory canal (IAC); the significance of these radiographic features on postoperative outcomes remains unclear. This study quantifies the impact of brainstem compression (BSC) and position relative to the IAC on surgical outcomes in VS.

methodsWe retrospectively identified 116 patients with sporadic unilateral VS ≥ 3 centimeters (2017-2022). Neurofibromatosis 2 cases were excluded. BSC was quantified with MRI T1 post-contrast axial images as the perpendicular distance from the brainstem-cerebellum to the point of maximal compression. Anterior and posterior IAC extension were measured relative to a line bisecting the IAC from the porus to fundus. Outcomes included postoperative facial nerve (FN) function, extent of resection (EOR), and length of stay (LOS).

resultsGreater anterior extension was associated with decreased EOR in univariate analysis (OR = 1.12, p = 0.03), but not after controlling for tumor size and age (OR = 1.09, p = 0.158). Greater BSC was associated with worse FN function at 2-3 weeks postoperatively on univariate (OR = 1.08, p = 0.036) and approached significance on multivariate analysis (OR = 1.07, p = 0.08). Posterior extension was associated with increased LOS in univariate (β = 217.57 min, p = 0.024), but not multivariate analysis. Neither anterior extension nor BSC were associated with LOS. Older age correlated with a lower rate of GTR and longer LOS in multivariate analysis (EOR: OR = 1.05, p = 0.003; LOS: β = 79.84 min, p = 0.026).

conclusionBSC is a radiographic feature that may be associated with short-term FN outcomes. EOR and LOS do not appear to be influenced by anterior or posterior extension, respectively, but rather appear to be confounded by age. These findings may inform individualized preoperative counseling and surgical planning for large VS.

Indexed as

Brain StemMagnetic Resonance ImagingNeuroma, AcousticNeurosurgical ProceduresAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesTreatment OutcomeAcoustic neuromaBrainstem compressionInternal auditory canalOutcomesTumor extensionVestibular schwannoma

Identifiers

PMID42234057
PMCPMC13234037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.