Evidence map›Paper›PMID 42234053›Full record

ArticleJournal of cardiovascular translational research2026

SLC11A1 Drives Ferroptosis in Acute Myocardial Infarction Via Sp1-mediated Transcriptional Repression of GPX4.

Shirong Zhang, Yeshu Wang, Yangmei Feng, Fang Wang, Jiaqing Zhu

Abstract read
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Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shirong ZhangDepartment Intens Care Unit, Hangzhou TCM Hospital affiliated to Zhejiang Chinese Medical University, No.453, Stadium Road, Hangzhou, Zhejiang, 310007, China.
Yeshu WangDepartment Intens Care Unit, Hangzhou TCM Hospital affiliated to Zhejiang Chinese Medical University, No.453, Stadium Road, Hangzhou, Zhejiang, 310007, China.
Yangmei FengDepartment Intens Care Unit, Hangzhou TCM Hospital affiliated to Zhejiang Chinese Medical University, No.453, Stadium Road, Hangzhou, Zhejiang, 310007, China.
Fang WangDepartment Intens Care Unit, Hangzhou TCM Hospital affiliated to Zhejiang Chinese Medical University, No.453, Stadium Road, Hangzhou, Zhejiang, 310007, China.
Jiaqing ZhuDepartment Intens Care Unit, Hangzhou TCM Hospital affiliated to Zhejiang Chinese Medical University, No.453, Stadium Road, Hangzhou, Zhejiang, 310007, China. drzhujiaqing@163.com.ORCID 0009-0003-0333-0283

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a critical contributor to cardiomyocyte injury in acute myocardial infarction (AMI). This study aimed to identify key ferroptosis-associated genes and elucidate their roles in AMI. Transcriptomic datasets from AMI patients and healthy controls were analyzed to identify differentially expressed genes (DEGs). The role of the solute carrier family 11 member 1 (SLC11A1) was validated in vitro using a hypoxia/reoxygenation (H/R) model in H9c2 cardiomyocytes and in vivo using a murine AMI model. SLC11A1 expression was elevated in H/R-treated cardiomyocytes and infarcted murine hearts. SLC11A1 silencing reduced infarct size and improved cardiac function, and suppressed ferroptosis. Mechanistically, SLC11A1 led to the transcriptional suppression of glutathione peroxidase 4 (GPX4) mediated by the transcription factor specificity protein 1 (Sp1). This study identifies the SLC11A1-Sp1-GPX4 axis as a pivotal transcriptional regulator pathway driving ferroptosis in AMI. These findings highlight SLC11A1 as a promising therapeutic target in AMI.

Indexed as

Cation Transport ProteinsFerroptosisMyocardial InfarctionMyocardial Reperfusion InjuryMyocytes, CardiacPhospholipid Hydroperoxide Glutathione PeroxidaseSp1 Transcription FactorAnimalsCell LineDisease Models, AnimalGene Expression Regulation, EnzymologicHumansMaleMice, Inbred C57BLRatsSignal TransductionCation Transport Proteinsglutathione peroxidase 4, mouseglutathione peroxidase 4, ratPhospholipid Hydroperoxide Glutathione PeroxidaseSP1 protein, humanSp1 Transcription FactorAcute myocardial infarctionFerroptosisGene therapyGPX4SLC11A1Sp1

Identifiers

PMID42234053

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.