ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026
The gut-bone-inflammation axis: intestinal barrier disruption as a central driver of osteoporosis.
Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is a systemic skeletal disorder traditionally attributed to imbalances in bone metabolism. Increasing evidence suggests that the intestinal environment and chronic inflammation play important roles in itspathogenesis. The gut-bone-inflammation axis provides a novel perspective for understanding the interactions among intestinal barrier function, immune regulation, and bone homeostasis. This review aims to summarize current evidence regarding the role of intestinal barrier disruption in osteoporosis and to discuss its contribution within the framework of the gut-bone-inflammation axis. Relevant experimental and clinical studies from the existing literature were reviewed and synthesized, with a focus on intestinal barrier integrity, gut microbiota dysbiosis, inflammatory mediators, immune activation, and bone metabolism. Disruption of the intestinal barrier increases intestinal permeability, facilitating the translocation of microbial products and pro-inflammatory mediators into the systemic circulation. This process promotes chronic low-grade inflammation, enhances osteoclast differentiation and activity, suppresses osteoblast function, and disrupts the balance of bone remodeling. Gut microbiota imbalance, immune activation, and sustained inflammatory signaling collectively contribute to bone loss and structural deterioration in osteoporosis. Intestinal barrier dysfunction plays a pivotal role in osteoporosis through modulation of systemic inflammation and bone metabolism. Strategies aimed at preserving intestinal barrier integrity and regulating the gut microbiota may offer promising preventive and therapeutic approaches for the management of osteoporosis.
Indexed as
Identifiers
42234035What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.