Evidence map›Paper›PMID 42233997›Full record

ArticleMolecular genetics and genomics : MGG2026

Therapeutic target exploration of Shugan Jianpi formula in liver fibrosis: an integrated lncRNA-mRNA co-expression network analysis.

Kaiqiang Wan, Qiong Zhou, Ruirui Feng, Chang Fan, Weibing Shi, Wenbin Xu, Hui Jiang, Qiumei Zhou

Abstract read
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In one paragraph

Article in Molecular genetics and genomics : MGG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaiqiang Wan *Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.ORCID http://orcid.org/0009-0001-7295-6066
Qiong Zhou *Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Ruirui Feng *Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Chang FanExperimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Weibing ShiDepartment of Hepatology and Infectious Diseases, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Wenbin XuDepartment of Hepatology and Infectious Diseases, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Hui JiangExperimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China. jianghui@ahtcm.edu.cn.
Qiumei ZhouExperimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China. zhouqiumei.2008@163.com.

Funding

Anhui Provincial Health and Health Research Project AHWJ2024Aa2036Anhui Provincial Higher Education Natural Science Research Project 2024AH050943National Natural Science Foundation of China No.82004139
6 · The paper itself

Abstract

Shugan Jianpi Formula (SGJPF), a traditional Chinese herbal formulation, has been clinically used for decades in the management of various chronic liver diseases, including liver fibrosis (LF). Previous studies have demonstrated the efficacy of SGJPF in ameliorating pathological manifestations in murine models of LF. However, the precise molecular mechanisms underlying its therapeutic effects remains unclear. In the present study, we aimed to explore the therapeutic mechanisms of SGJPF through comprehensive analysis of LncRNA-mRNA co-expression network.The therapeutic efficacy of SGJPF in a CCL

Indexed as

Drugs, Chinese HerbalGene Regulatory NetworksLiver CirrhosisRNA, Long NoncodingRNA, MessengerAnimalsDisease Models, AnimalGene Expression ProfilingGene Expression RegulationLiverMaleMiceSignal TransductionTranscriptomeDrugs, Chinese HerbalRNA, Long NoncodingRNA, MessengerLiver fibrosisLong non-coding RNA (LncRNA)Messenger RNA (mRNA)Shugan Jianpi formulaTraditional chinese medicineWhole transcriptome sequencing

Identifiers

PMID42233997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.