Evidence map›Paper›PMID 42233931›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2026

Weight Loss Medications in Youth: Decision-Making Experiences, Eating Behaviors, and Uncertainty About Endpoint.

Hilla Nehushtan, Rawan Elrajabi, Vaishnavi Peyyety, Sarah Apte, Rutha Chivate, Alexandra Anderson, Margaret Jankowski, Emir Tas, Christine A March, Caroline Christian and 2 more

Abstract read
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hilla NehushtanThe Dietrich School of Arts & Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Rawan ElrajabiDivision of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Vaishnavi PeyyetyDivision of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Center for Pediatric Research in Obesity and Metabolism, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Washington & Jefferson College, Washington, Pennsylvania.
Sarah ApteNortheast Ohio Medical University, Rootstown, Ohio.
Rutha ChivateUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Alexandra AndersonUPMC Magee-Womens Hospital, Pittsburgh, Pennsylvania.
Margaret JankowskiDivision of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Center for Pediatric Research in Obesity and Metabolism, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Emir TasDivision of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Center for Pediatric Research in Obesity and Metabolism, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Christine A MarchDivision of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Caroline ChristianThe Dietrich School of Arts & Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Andrea B GoldschmidtDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Mary Ellen VajraveluDivision of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; Center for Pediatric Research in Obesity and Metabolism, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: MaryEllen.Vajravelu@pitt.edu.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
CARDIOVASCULAR BEHAVIORAL MEDICINE RESEARCH TRAININGT32HL007560 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter J Gianaros, REBECCA C THURSTON · 1985 to 2026
$11.3M
NCATS NIH HHS UL1 TR001857NHLBI NIH HHS T32 HL007560
6 · The paper itself

Abstract

purposeTo examine decision-making and experiences with use of weight loss medications by adolescents and young adults (AYAs) with obesity.

methodsParticipants included AYA 12-22 years old with obesity who were considering starting (PRE) or were using weight loss medications (POST), including semaglutide, liraglutide, tirzepatide, or phentermine ± topiramate. Caregivers of AYA participants were also invited to participate. Semistructured interviews were audio recorded on a video conferencing platform by trained research team members. A rapid qualitative analysis approach was used to summarize themes.

resultsA total of 29 AYA (9 PRE, 20 POST; 55% female; mean age 16.7 ± 2.5 years) and 23 caregivers (7 PRE, 16 POST; 22 mothers, 1 grandmother) participated. Themes included: decision-making: family, peers, doctors, media, finances, and risk-benefit considerations were influential, with AYAs emphasizing weight loss and caregivers emphasizing health; appetite and eating behaviors: high appetite was a key reason for use, "binges" were reported by PRE AYA and POST AYA pretreatment, and medications reduced appetite and food noise; physical, mental, and social experience: improved AYA well-being was reported, yet stigma about medication usage was a concern; parental role: parents provided key practical and emotional support for use; and thinking about future use: AYA and caregivers expressed positive experiences overall and uncertainty over discontinuation decisions. DISCUSSION: A shared decision-making approach leveraging caregiver support for initiation, ongoing use, and discontinuation is needed for AYA considering weight loss medications. Future research should investigate strategies to assess for disordered eating in this population.

Indexed as

Anti-Obesity AgentsDecision MakingFeeding BehaviorObesityAdolescentChildFemaleHumansMaleQualitative ResearchSemaglutideUncertaintyWeight LossYoung AdultAnti-Obesity AgentsSemaglutideAdolescentDisordered eatingObesityStigmaWeight loss medications

Identifiers

PMID42233931
PMCPMC13679181

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.