Evidence map›Paper›PMID 42233660›Full record

ArticlemSystems2026

Decoding the interactome for cyclic-di-AMP-producing enzyme diadenylate cyclase.

Rong Mu, Baotong Xie, Stephanie Momeni, Hui Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rong MuDepartment of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0001-6846-3659
Baotong XieDepartment of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Stephanie MomeniDepartment of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0002-0883-104X
Hui WuDepartment of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0003-1694-3954

Funding

SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
NIDCR NIH HHS R01DE022350
6 · The paper itself

Abstract

In many gram-positive bacteria, the diadenylate cyclase DacA synthesizes the essential second messenger c-di-AMP. While regulators like GlmM and CdaR are known, the broader DacA interactome and its functional relevance remain poorly defined. Using IMPORTANCE: Mapping the DacA interactome reveals how environmental and intracellular cues tune c-di-AMP signaling to control stress adaptation, ion balance, and virulence traits in

Indexed as

Bacterial ProteinsDinucleoside PhosphatesPhosphorus-Oxygen LyasesStreptococcus mutansAnimalsProtein BindingBacterial Proteinscyclic diadenosine phosphateDinucleoside PhosphatesPhosphorus-Oxygen Lyasesdiadenylate cyclaseprotein-protein interactionsStreptococcus mutans

Identifiers

PMID42233660
PMCPMC13289029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.