Evidence map›Paper›PMID 42233658›Full record

ArticlemSystems2026

Environmental fungi modulate the vaginal mycobiome and cervical disease progression in Hispanic women.

Filipa Godoy-Vitorino, Daniela Vargas-Robles, Benjamin Bolaños-Rosero, Natalia Pagán-Zayas, Andrea Cortés-Nazario, Kara Wiggin, Sarah Allard, Josefina Romaguera, Jack A Gilbert

Abstract read
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Immune remodeling in HPV-associated cervical disease.Frontiers in cellular and infection microbiology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Filipa Godoy-VitorinoDepartment of Microbiology and Immunology, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA.ORCID 0000-0003-1880-0498
Daniela Vargas-RoblesDepartment of Microbiology and Immunology, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA.
Benjamin Bolaños-RoseroDepartment of Microbiology and Immunology, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA.
Natalia Pagán-ZayasDepartment of Microbiology and Immunology, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA.
Andrea Cortés-NazarioDepartment of Microbiology and Immunology, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA.
Kara WigginDepartment of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
Sarah AllardDepartment of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
Josefina RomagueraDepartment of Obstetrics and Gynecology, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA.
Jack A GilbertDepartment of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Souhail M Malave-Rivera · 2017 to 2026
$35.8M
NIH HHS P20 GM103475-23, P50GM133807-06, 5U54MD007600-39NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

The vaginal mycobiome, though a minor component of the cervicovaginal ecosystem, plays a crucial role in reproductive health and disease. However, its composition and interactions with bacterial communities remain poorly understood, particularly among Hispanic women, who experience disproportionately high rates of human papillomavirus (HPV) infection and cervical cancer. We characterized the vaginal mycobiota across reproductive stages and examined its associations with cervical disease, HPV status, and bacterial community state types (CSTs) in 86 Hispanic participants from Puerto Rico using ITS1 amplicon sequencing. Amplicon sequence variants were inferred with QIIME2/DADA2 and taxonomically classified using the UNITE database, with diversity and discriminant taxa analyses applied to explore clinical and microbial associations. We detected 173 fungal species hypotheses, dominated by

Indexed as

FungiMycobiomeUterine Cervical NeoplasmsVaginaAdultDisease ProgressionFemaleHispanic or LatinoHumansMiddle AgedPapillomavirus InfectionsPuerto RicoYoung AdultfungiHispanic womenhuman papillomavirusvaginal microbiotawomen's health

Identifiers

PMID42233658
PMCPMC13289163

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.