Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Renata de Azevedo Melo LuvizottoDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.ORCID 0000-0001-9548-6338
André F NascimentoDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.ORCID 0000-0001-6118-2133
Gustavo F PimentaDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.
Rafael M de CostaDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.
Tyler BelingDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.
Shubhnita SinghChildren's Hospital of Philadelphia (CHOP), Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States.ORCID 0000-0002-1835-2317
Juliano V AlvesDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
Wanessa M C AwataDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.ORCID 0000-0002-8925-9929
Angela RussDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, United States.ORCID 0009-0005-0157-2478
Adeyeye Isaac HaastrupDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, United States.ORCID 0009-0006-8577-1454
Rolando A CuevasPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-3571-5845
Parya BehzadiPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-3807-1109
Cynthia St HilairePittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-1871-6915
Justin T RobertsDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, United States.ORCID 0000-0003-4433-1234
Ariane BruderDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.ORCID 0009-0005-7067-4048
Thiago Bruder-NascimentoDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.ORCID 0000-0001-5671-318X
Funding
Molecular mechanisms of progranulin as a regulator of endothelial biology and blood pressure controlR01HL169202 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Thiago Bruder · 2024 to 2026
$1.5M
Medial Arterial Calcification in Peripheral Artery DiseaseR01HL176595 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Cynthia St. Hilaire · 2025 to 2026
$1.5M
American Heart Association (AHA) CDA857268HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL169202NHLBI NIH HHS R01 HL169202NHLBI NIH HHS R01 HL176595
6 · The paper itself
Abstract
Cellular senescence-an age-associated state characterized by irreversible cell cycle arrest and proinflammatory signaling-contributes to vascular dysfunction and cardiovascular disease. However, the molecular mechanisms linking senescence to vascular impairment remain incompletely defined. Progranulin (PGRN) is a multifunctional protein involved in inflammation, lysosomal function, and cellular homeostasis, but its role in vascular aging is not well understood. We assessed PGRN expression in human and mouse arteries and in senescent vascular smooth muscle cells (VSMCs). Vascular function was examined in PGRN-deficient (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Progranulin deficiency induces premature vascular senescence and dysfunction. · full record | OpenQuestion