ArticleAmerican journal of physiology. Heart and circulatory physiology2026
Left ventricular chamber stiffness and strain determines the myocardial transcriptional response to elevated filling pressure.
Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Transient hypertension precedes sustained hypertension and can arise from reduced aortic compliance with aging. We recently demonstrated that daily hypertension transients in swine rapidly lead to irreversible increases in left ventricular (LV) chamber stiffness without the development of anatomic hypertrophy (LVH). This dissociation was surprising and led us to hypothesize that the transcriptional response to pressure overload was determined by LV diastolic chamber stiffness. Myocardial tissue for RNASeq was obtained 24 h after transient pressure elevation (left ventricular end-diastolic pressure from 12.2 ± 0.8 mmHg to 34.3 ± 2 mmHg and LVSP from 105 ± 3 mmHg to 223 ± 8 mmHg) using phenylephrine. Animals with a single episode [single pressure overload (SPO),
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.