Evidence map›Paper›PMID 42233517›Full record

ArticleFunction (Oxford, England)2026

Layer-specific choroidal vascular adaptation to high-altitude hypoxia revealed by functional OCT at 3,800 m.

Mohammad Amin Safarzadeh, Jacquie R Baker, Satish R Raj, Usman Alim, Trevor A Day, Nicholas G Jendzjowsky, Richard J A Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Function (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Mohammad Amin SafarzadehDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Jacquie R BakerDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-2346-2761
Satish R RajLibin Cardiovascular Institute, Cumming School of Medicine, Calgary, Alberta, Canada.
Usman AlimDepartment of Computer Science, University of Calgary, Calgary, Alberta, Canada.
Trevor A DayDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Nicholas G JendzjowskyDivision of Respiratory and Critical Care Physiology and Medicine, David Geffen School of Medicine UCLA, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States.
Richard J A WilsonDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-9942-4775

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ascent to high-altitude induces systemic and ocular changes that alter vision. The functional responses of the choroidal vasculature at different depths to hypoxia remain incompletely understood. In this study, we used functional optical coherence tomography (f-OCT) to quantify changes in choroidal vascular perfusion density (VPD) across superficial, deep, and total choroidal layers in 16 healthy participants. Imaging was performed at baseline (1,100 m) and during acute (

Indexed as

Adaptation, PhysiologicalAltitudeAltitude SicknessChoroidHypoxiaTomography, Optical CoherenceAdultFemaleHumansMaleRegional Blood FlowYoung Adultchoroidal perfusionfunctional optical coherence tomographyhigh-altitude hypoxianeuro-ocular physiologyvascular regulation

Identifiers

PMID42233517
PMCPMC13290071

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.