Evidence map›Paper›PMID 42233508›Full record

Trial reportJournal of adolescence2026

Positive Affect as a Transdiagnostic Target for Reducing Adolescent Depression & Suicide Risk: Do Mindfulness, Savoring, & Gratitude Help?

Natalia Macrynikola, Jackson Doerr, Shirley Yen

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of adolescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natalia MacrynikolaHarvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2988-5503
Jackson DoerrHarvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Shirley YenHarvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7194-1380

Funding

Skills to Enhance Positivity in Suicidal AdolescentsR34MH101272 · NIMH · BROWN UNIVERSITY · PI YEN, SHIRLEY · 2013 to 2015
$746k
NIMH NIH HHS R34 MH101272
6 · The paper itself

Abstract

introductionDespite its known contribution to adolescent depression and suicide risk, low positive affect (PA) remains underemphasized in clinical interventions, with limited evidence on how to best enhance it. Using data from a pilot randomized controlled trial of a brief PA-enhancing intervention for high-risk youth, we hypothesized that increases in PA over the intervention period would prospectively predict lower depressive symptoms and suicide ideation (SI). We also hypothesized that increases in mindfulness, savoring, and gratitude would prospectively predict higher PA and lower depressive symptoms and SI.

methodsParticipants were 52 adolescents, ages 12-18 (62% female, 31% male, 8% transgender) hospitalized for suicide-related reasons in the northeastern U.S.

resultsPA increases (using an anhedonia measure, where lower scores reflect greater PA) predicted lower T2 depressive symptoms, B = 1.00, p < 0.01, and lower T2 SI, B = 3.04, p < 0.01. Mindfulness increases predicted lower T2 depressive symptoms, B = -14.55, p < 0.01, and were marginally associated with lower T2 SI, B = -23.93, p = 0.08. Savoring increases predicted lower T2 depressive symptoms, B = -3.68, p < 0.05, and lower T2 SI, B = -17.50, p < 0.01. Gratitude increases were marginally associated with T2 depressive symptoms, B = -0.68, p = 0.07, but not T2 SI. Mindfulness, savoring, and gratitude increases were significant predictors of higher T2 PA. All analyses adjusted for T1 scores.

conclusionFindings support PA as a transdiagnostic target for adolescent depression and suicide risk. When developmentally tailored, mindfulness, savoring, and gratitude strategies may help enhance PA. Larger studies are needed to confirm these preliminary findings.

Indexed as

AffectDepressionMindfulnessSuicidal IdeationSuicide PreventionAdolescentChildFemaleHumansMaleadolescentsdepressiongratitudemindfulnesspositive affectsavoringsuicide risk

Identifiers

PMID42233508
PMCPMC13440738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.