ArticleAngewandte Chemie (International ed. in English)2026
Pyridine C─N Transposition via Cycloaddition-Cycloreversion.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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2 authors.
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Abstract
The selective incorporation of nitrogen atoms is fundamental to the design and synthesis of drugs and other functional molecules. Here, we describe a skeletal-editing approach to the transposition of pyridine nitrogen atoms, creating a route to 3-alkylated pyridines that are difficult to access using current methods. The reaction uses a cycloaddition/cycloreversion strategy (CACR) to transpose easily made 4-aryl and alkyl pyridines into the more challenging meta-functionalized isomers. The cycloaddition reaction introduces versatile sulfone functionality, that can be harnessed for further C─X and C─C bond formations for pyridine synthesis.
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