ArticleJournal of the science of food and agriculture2026
Comparative assessment on osteoprotective effects of bone collagen peptides from diverse animal sources: Insights from the characteristics of gastrointestinal digestion and absorption.
Article in Journal of the science of food and agriculture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundAlthough livestock and poultry bone collagen peptides (LBPs) have been reported to exhibit protective effects against osteoporosis, the in vitro osteogenic and in vivo anti-osteoporotic bioactivity of LBPs may vary depending on the animal sources, and the underlying mechanisms remain unclear. The present study aimed to investigate the divergence in the osteoprotective effects of yak (YBPs)/bovine (BBPs)/porcine (PBPs)/chicken (CBPs) bone collagen peptides, and to elucidate how gastrointestinal digestion and absorption characteristics contribute to their distinct osteoprotective mechanisms.
resultsYBPs/BBPs exhibited the highest osteoprotective effects, whereas PBPs exhibited weaker in vitro osteogenic but stronger in vivo anti-osteoporotic bioactivity than CBPs. Four osteogenic peptides were obtained by virtual screening, their retention rates after simulated gastrointestinal digestion and apparent permeability coefficients in a Caco-2 monolayer model ranged from 12.95% to 30.13% and 0.15 to 0.55 × 10
conclusionThe divergent osteoprotective effects of YBP/BBPs/PBPs/CBPs are likely attributable to their structural determinants including gastrointestinal digestion/absorption/transportation, and affinity/binding modes to epidermal growth factor receptor, as well as possible RGD (arginine, glycine and aspartic acid) sequence similarity. These findings provide mechanistic insights and identify potential molecular targets for optimizing peptide-based functional food ingredients for bone health. © 2026 Society of Chemical Industry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.