ReviewEssays in biochemistry2026
When context matters: community and environmental context to elicit natural products.
Review in Essays in biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Considering internal conflict in the face of natural product biosynthesis and biosynthetic gene cluster evolution.Essays in biochemistry · 2026Review
- Bacterial biosynthetic gene clusters.Essays in biochemistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Natural products (NPs) comprise a wide range of bioactive compounds, including therapeutics and antibiotics. Despite several efforts, the discovery of novel NPs has been hindered by frequent rediscoveries of previously known NPs. Computational tools, such as those in genome mining, have helped identify the biosynthetic gene clusters (BGCs) responsible for the biosynthesis of NPs. However, there is a disconnect between the number of uncharacterized BGCs and the number of observed NPs in laboratory conditions. Considering the community and environmental context (C&EC) of NP-producing organisms can inform elicitation strategies to produce novel, uncharacterized NPs. Approaches inspired by nature, such as mimicking environmental conditions, introducing NPs as elicitors, and using multispecies co-cultures, have been proven successful in eliciting different responses in NP biosynthesis in the laboratory. However, the principles that drive how environmental conditions regulate NPs remain poorly understood. Integrating C&EC with genomic and metabolomic data enables the development of more rational, ecology-informed strategies for eliciting silent BGCs and discovering novel NPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.