ArticleHypertension (Dallas, Tex. : 1979)2026
Impact of Gestational Weight Gain and Maternal Weight on Sympathetic Adaptations.
Article in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundExcessive gestational weight gain (GWG) may cause maladaptive sympathetic neural responses and increase pregnancy risk, which may differ by maternal body mass index. We hypothesized that excessive GWG would further increase muscle sympathetic nerve activity across gestation, particularly in women with overweight or obesity.
methodsNinety pregnant women were studied longitudinally during early and late gestation and postpartum. Participants were classified by body mass index in early pregnancy and by GWG in late pregnancy based on the 2009 Institute of Medicine guidelines, forming 4 groups: normal-weight women with normal (n=17) or excessive GWG (n=26), and overweight/obese women with normal (n=16) or excessive GWG (n=31). Resting systolic and diastolic blood pressure, heart rate, and muscle sympathetic nerve activity were measured. Pregnancy outcomes were obtained from hospital maternity records, and complications were diagnosed according to established clinical criteria.
resultsMuscle sympathetic nerve activity increased across gestation and was greater in overweight/obese groups than in normal-weight groups (
conclusionsThe changes in muscle sympathetic nerve activity across gestation did not differ by GWG, even among women with overweight/obesity, suggesting that the increased risk from excessive GWG is unlikely to be mediated by sympathetic activity.
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