Trial reportCancer medicine2026
High-Intensity Interval Training Boosts Immune Cells in Advanced Cancer Patients and Healthy Controls: Implications for Cancer Care.
Trial report in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05656651 (ACTIVE- Acute Effects of a Single Physical Exercise Intervention on Immune Cells and Inflammation in Cancer Patients and a Healthy Comparison Group), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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ACTIVE- Acute Effects of a Single Physical Exercise Intervention on Immune Cells and Inflammation in Cancer Patients and a Healthy Comparison Group
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9 authors.
Funding
Abstract
backgroundRegular exercise improves quality of life (QoL) and reduces fatigue in advanced cancer patients (ACP), but acute immune responses are underexplored. This study investigated the effects of a single high-intensity interval training (HIIT) session on natural killer (NK) cells and circulating innate lymphoid cells (cILCs) in ACP.
methodsAn ACP group undergoing chemotherapy (PG, n = 20, 59.8 ± 10.3 years, 70% pancreatic cancer) was compared with age-matched healthy controls (HG, n = 19, 60.7 ± 10.6 years). Both groups completed a 20-min HIIT session. Blood samples were collected before (T0), immediately after (T1), and 1 h post-exercise (T2). NK cells, cILCs, and subsets were analyzed via flow cytometry. Patient-reported outcomes (QoL, fatigue, nutrition) were assessed with validated questionnaires.
resultsA single HIIT session induced a significant (PG: p = 0.001; HG: p = 0.045) increase in the number of circulating total NK cells immediately after exercise in both groups, with a median within-subject increase of 50% in the PG and 38% in the HG, followed by a significant (PG/HG: p < 0.001) decrease during the recovery period (PG: -43%, HG: -69%). cILCs increased significantly (PG: p = 0.005; HG: p = 0.001) only during the exercise period in both groups, with a median within-subject increase of 21% in the PG and 55% in the HG. Differences were observed between groups and across individual immune cell subpopulations. NK responses positively correlated with higher training heart rate in both groups, and additionally with BMI (HG, cILC2) and age (PG, CD56
conclusionA single HIIT session transiently mobilized NK cells and cILCs in ACP undergoing chemotherapy. These results indicate that acute HIIT is feasible in this population and provide hypothesis-generating evidence on exercise-induced changes in immune cell counts.
trial registrationThe study was registered at 13.11.2022, registration number NCT05656651.
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