ArticleIndian journal of palliative care
Translation and Validation of the Khasi version of European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C-30) and Oesophageal Cancer module (EORTC QLQ-OES-18).
Article in Indian journal of palliative care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Oesophageal cancer (OC) is characterised by poor prognosis, a significant reduction in Quality of Life (QoL) and requirement for morbid therapy. The highest age-adjusted rate of OC incidence in India was seen in the East Khasi Hills district of Meghalaya, being 10 times the national average. This study aimed to develop and validate Khasi translations of the European Organisation for Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C-30) Version 3.0 and EORTC QLQ-OES-18 questionnaires for use in the Khasi-speaking population of Meghalaya. Materials and Methods: This study was conducted as a part of a hospital-based cross-sectional study to develop and validate a Khasi-translated version of the QLQ-C-30 and QLQ-OES-18 questionnaires. The questionnaire was translated into the local (Khasi) language and validated (two-phase process: Two forward translations, two backward translations, followed by pilot testing). Reliability assessment was done using Cronbach's alpha. The construct validity and the correlation of each scale of the QLQ-C30 and QLQ-OES18 were evaluated using Spearman's correlation coefficient (r). Results: Cronbach's alpha was satisfactory (>0.70) for all the scales of QLQ-C-30 and QLQ-OES-18. Convergent validity was moderate to high (r = 0.541 to 0.995) (Global health domain convergent validity r = 0.983-0.995), whereas discriminant validity was acceptably low (Global health domain divergent validity of r = 0.006-0.474) for all scales. Correlation coefficient values for each scale between QLQ-C-30 and QLQ-OES-18 ranged from 0.001 to 0.557. Conclusion: The Khasi versions of the QLQ-C-30 and QLQ-OES-18 demonstrate good psychometric validity, proving to be a reliable and culturally appropriate valuable tool for assessing QoL in OC patients in the Khasi-speaking population of North-East India.
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