ArticleFrontiers in toxicology2026
Compositional profiling for biodegradable medical devices: a framework for degradation-informed exposure and risk assessment.
Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Biodegradable polymers (BPs) present unique challenges for chemical characterization and toxicological risk assessment. Methodological requirements for devices with prolonged tissue contact often involve exhaustive extraction-an approach impractical for many BPs due to their degradability and incompatibility with common solvents. This paper proposes a hybrid approach to TRA for BPs, beginning with compositional profiling to estimate the total quantity of each polymer in a device and applying worst-case assumptions for complete hydrolysis into monomeric constituents. A biodegradable vessel closure system composed of a glycolide-caprolactone-trimethylene carbonate (GA-CL-TMC) copolymer, combined with a poly(glycolide-lactide) (PLGA) suture and polyethylene glycol (PEG) sealant, is applied as a case study. Estimated exposure doses (EED
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