ReviewFrontiers in immunology2026
The immune-endothelial axis in neurovascular pathophysiology: a framework for targeted interventions.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebrovascular endothelium has been reconceptualized from a mere passive barrier to an active regulator of neuroimmune responses. The interaction between immune cells and endothelial cells, particularly at the blood-brain barrier, is pivotal in the context of neuroinflammation and vascular dysfunction associated with various neurological disorders. This comprehensive review synthesizes recent advancements in the molecular and cellular mechanisms that govern this interaction. We investigate how activated endothelial cells interact with immune cells through adhesion pathways, cytokine networks, and metabolic cross-talk, thereby contributing to the pathogenesis of disease. Special attention is given to the influence of vascular aging in exacerbating this dysregulation. Additionally, we assess the translational implications of our findings, including the identification of novel biomarkers, advancements in neuroimaging techniques, and therapeutic strategies aimed at restoring barrier integrity and modulating neuroimmune responses. A comprehensive understanding of the immune-endothelial axis provides a crucial framework for elucidating neurovascular pathophysiology and informing targeted interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.