Evidence map›Paper›PMID 42233023›Full record

ArticleFrontiers in immunology2026

Aberrant IL-21/STAT3 signaling disrupts regulatory T cell function and CD4

Xiaofeng Sun, Jiou Zhao, Jin Liu, Wendi Zhou

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaofeng SunDepartment of Pediatrics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
Jiou ZhaoDepartment of Pediatrics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
Jin LiuDepartment of Pediatrics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
Wendi ZhouDepartment of Pediatrics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Type 1 diabetes (T1D) is an autoimmune disease characterized by profound dysregulation of CD4 Methods: Single-cell RNA sequencing data from children with T1D were analyzed to characterize IL-21/STAT3 pathway activity across immune cell subsets. Functional assays were performed using primary human CD4 Results: Single-cell transcriptomic analysis revealed enhanced IL-21/STAT3 signaling activity in CD4 Conclusion: Aberrant activation of the IL-21/STAT3 signaling axis may contribute to impaired Treg function and CD4

Indexed as

CD4-Positive T-LymphocytesDiabetes Mellitus, Type 1InterleukinsSignal TransductionSTAT3 Transcription FactorT-Lymphocytes, RegulatoryAdolescentAnimalsChildChild, PreschoolFemaleHomeostasisHumansInterleukin-21MaleMiceInterleukin-21InterleukinsSTAT3 protein, humanSTAT3 Transcription Factorautoimmune immunityCD4+ T cellsIL-21/STAT3 signalingregulatory T cellsT cell homeostasistype 1 diabetes

Identifiers

PMID42233023
PMCPMC13223116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.