ArticleFrontiers in immunology2026
Obstructive sleep apnea is linked to inflammatory changes and motor impairment in Parkinson's disease.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Obstructive sleep apnea (OSA) is prevalent among patients with Parkinson's disease (PD), yet its contribution to neuroinflammation and disease progression remains poorly understood. This study investigated the association between OSA severity, sleep parameters, and systemic cytokine/chemokine profiles in PD. Methods: In this cross-sectional study, 48 patients underwent clinical evaluation, polysomnography (PSG), and multiplex cytokine profiling. Participants were classified as PD+OSA Results: OSA was diagnosed in 54.2% of PD patients and was associated with older age, poorer quality of life, and higher UPDRS-II/III scores (p < 0.05). The PD+OSA Discussion: OSA is a prevalent disorder in PD, affecting over half of the patients, and is linked to sleep fragmentation and a proinflammatory environment driven by Th1/Th2 and chemokine signaling, which may contribute to worsening motor and non-motor symptoms.
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