ArticleFrontiers in medicine2026
Phacoemulsification with IOL implantation combined with goniosynechialysis and goniotomy in primary angle-closure glaucoma following failed trabeculectomy: short-term effectiveness and safety outcomes.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To evaluate the short-term effectiveness and safety of Phacoemulsification with intraocular lens implantation combined with goniosynechialysis and goniotomy (PEI-GSL-GT) in eyes with prior failed trabeculectomy compared to surgically naïve eyes. Materials and methods: This retrospective study enrolled 40 eyes (34 patients) diagnosed with moderate to advanced primary angle-closure glaucoma (PACG) who received treatment at the Eye Hospital of Nanjing Medical University from November 2024 to November 2025. After excluding one patient lost to follow-up, 39 eyes (33 patients) with at least 3 months of follow-up were finally included. Among them, 17 cases underwent reoperation due to previous trabeculectomy failure, while 22 cases received the surgical intervention for the first time. All eyes underwent the PEI-GSL-GT procedure. The cohort was divided into a Naïve Group (no prior glaucoma surgery) and a Trabeculectomy failure group (prior failed trabeculectomy). Main outcome measures included intraocular pressure (IOP), best-corrected visual acuity (BCVA), the number of anti-glaucoma medications, and postoperative complications. Surgical success was analyzed using Kaplan-Meier survival curves. Results: Baseline characteristics were comparable between the Naïve ( Conclusion: PEI-GSL-GT was associated with significant IOP reduction and reduced medication burden during short-term follow-up. No statistically significant differences were observed between the Trabeculectomy failure group and Naïve groups in most outcomes during the 3-month follow-up.
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