ArticleGastro hep advances2026
Increased Prevalence of Advanced Adenomas in Younger Individuals Undergoing Early Screening Colonoscopy Due to a Family History.
Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background and Aims: Current guidelines recommend patients with a first-degree relative with advanced adenomas (AAs) identified <60 years old should initiate screening colonoscopy at age 40 or 10 years prior to their relative. Data on the prevalence of AAs and colorectal cancer in these patients, especially younger individuals, are lacking. This study determined the prevalence of AAs and colorectal cancer in younger individuals undergoing early screening colonoscopy due to a family history of advanced polyps. Methods: A retrospective case-control study performed at a large community practice identified 409 patients who underwent screening colonoscopy due to a first-degree relative with advanced polyps <60 years old ("FH" [family history]) and 11,441 patients without a family history ("control") who underwent a colonoscopy for abdominal pain or bowel changes between 2015 and 2023. Patients were divided into 3 age groups of 20-39, 40-45, and 45-49 years old for statistical analysis. The primary outcome was the detection of AAs. Results: The prevalence of AAs was greater in the FH group (n = 40) compared to the control group (n = 682) (9.8% vs 6.0%; Conclusion: A family history of AA was associated with an increased prevalence of advanced polyps in younger adults compared to a control population. Prospective research is needed to further evaluate the prevalence of AA in this population.
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