Evidence map›Paper›PMID 42232737›Full record

ArticleFood & nutrition research2026

Urolithin A supplementation alleviates osteogenic disfunction and promotes bone fracture healing in inflammatory environments.

Jinwu Bai, Jixing Fan, Ruideng Wang, Shilong Su, Daole Hu, Xi He, Shan Gao, Fang Zhou

Abstract read
In one paragraph

Article in Food & nutrition research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinwu Bai *Department of Orthopedics, Peking University Third Hospital, Beijing, China.
Jixing Fan *Department of Orthopedics, Peking University Third Hospital, Beijing, China.
Ruideng Wang *Department of Trauma Orthopedics, Shenzhen Second People's Hospital (The First Affiliated Hospital of Shenzhen University), Shenzhen, China.
Shilong SuDepartment of Orthopedics, Peking University Third Hospital, Beijing, China.
Daole HuDepartment of Orthopedics, Peking University Third Hospital, Beijing, China.
Xi HeKey Laboratory for Biomechanics and Mechanobiology (Beihang University) of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Shan GaoDepartment of Orthopedics, Peking University Third Hospital, Beijing, China.
Fang ZhouDepartment of Orthopedics, Peking University Third Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive and chronic inflammation can cause osteogenic dysfunction and disrupt the balance of the osteoimmune microenvironment, thereby increasing the risk of fracture non-union. Urolithin A (UA), a gut microbiota-derived metabolite produced from dietary sources, has been reported to inhibit RANKL-induced osteoclastogenesis and alleviate postmenopausal osteoporosis. However, the effect of UA on osteogenesis, particularly under pathogenic inflammatory conditions, remains unclear. In this study, mouse bone marrow-derived mesenchymal stromal cells (mBMSCs) were used to evaluate osteogenesis

Indexed as

inflammationmacrophage polarisationNF-κB pathwayosteogenesisUrolithin A

Identifiers

PMID42232737
PMCPMC13224938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.