Evidence map›Paper›PMID 42232724›Full record

ArticleAdvanced functional materials2026

Cardiac-Derived ECM Microspheres for Enhanced hiPSC-CMs Maturation.

Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiazhu XuDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.
Joel AboagyeDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.
Marcella EdwardsDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.
Nick RogozinskiDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.
Yufeng WenDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.
Angello Huerta GomezDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.
Zui PanDepartment of Graduate Nursing, University of Texas at Arlington, Arlington, Texas, USA.
Ge ZhangDepartment of Biomedical Engineering, The University of Akron, Akron, Ohio, USA.
Huaxiao YangDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.
Yi HongDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.ORCID 0000-0002-5846-2596

Funding

Bioactive adhesive material for early vaginal wall detachment in pelvic organ prolapseR01HD097330 · NICHD · UNIVERSITY OF TEXAS ARLINGTON · PI HONG, YI · 2019 to 2023
$1.6M
Elastic exosome-releasing conductive patches for heart repairR01HL175960 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI Ke Cheng, Yi Hong · 2025 to 2026
$1.4M
Assessing Tyrosine Kinase Inhibitors-induced Cardiotoxicity with an Organoid-AI SystemR56HL174856 · NHLBI · UNIVERSITY OF NORTH TEXAS · PI YANG, HUAXIAO · 2024 to 2024
$547k
Bioactive injectable blends for cardiac stem cell recruitmentR15HL140503 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI HONG, YI · 2018 to 2018
$460k
An Inverted Nikon A1R Laser Scanning Confocal MicroscopeS10OD025230 · OD · UNIVERSITY OF TEXAS ARLINGTON · PI PAN, ZUI · 2019 to 2019
$449k
NOTCH signaling on the underdeveloped cardiac vascularization of hypoplastic left heart syndrome in the hiPSC-derived vascularized cardiac organoidsR15HD108720 · NICHD · UNIVERSITY OF NORTH TEXAS · PI YANG, HUAXIAO · 2022 to 2022
$438k
American Heart Association-American Stroke Association 959644NHLBI NIH HHS R01 HL175960NHLBI NIH HHS R15 HL140503NHLBI NIH HHS R56 HL174856NICHD NIH HHS R01 HD097330NICHD NIH HHS R15 HD108720NIH HHS S10 OD025230
6 · The paper itself

Abstract

The phenotypic immaturity of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) remains a critical barrier to their effective use in disease models, drug screening, and cardiac regeneration. Current culture platforms still find it hard to provide a physiologically relevant, stable, and scalable microenvironment to support cardiomyocyte maturation. We report a reproducible heart tissue-derived cardiac extracellular matrix (ECM) microsphere that integrates native biochemical cues with a porous three-dimensional (3D) architecture to support cardiac cell culture and maturation. These microspheres supported the attachment and proliferation of C2C12, HL-1, H9c2, and hiPSC-CMs culture, suggesting the broad applicability of multiple cell types. Compared with the conventional two-dimensional (2D) culture system, decellularized cardiac ECM microspheres provided a spherical 3D culture interface and significantly enhanced hiPSC-CM maturation, as indicated by upregulation of cardiac genes (

Indexed as

Decellularized cardiac ECMhiPSC-CMsMaturationMicrosphere

Identifiers

PMID42232724
PMCPMC13225862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.