ReviewFrontiers in pediatrics2026
Risk factors associated with growth pain disorder in children: a systematic review and meta-analysis.
Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objective: To systematically evaluate the risk factors associated with growth pain disorder (GP) in children and provide an evidence-based reference for its clinical diagnosis and intervention. Methods: Seven electronic databases were searched from database inception to Oct 2025 to identify clinical studies investigating risk factors for GP in children. Two researchers independently screened the literature, extracted the data, and assessed the study quality. Statistical analyses were performed using Review Manager (version 5.4), and descriptive analyses were conducted for studies that could not be statistically analyzed. Results: A total of 37 studies involving 16,086 participants and reporting 17 potential risk factors were included. On the basis of the current evidence, compared with healthy children, children with GP had lower serum 25-hydroxyvitamin D (25(OH)D) concentrations (SMD = -2.75, 95% CI: -3.46 to -2.04; Conclusion: GP in children is affected by multiple factors, and our study offers a valuable reference for clinical diagnosis and treatment. However, owing to the heterogeneity and sample size of the included studies, the results should be interpreted with caution. More high-quality prospective studies are needed to further strengthen our understanding of the factors influencing GP in children. Systematic Review Registration: PROSPERO CRD420251150931.
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