Neuroinflammation and white matter microstructure as mediators of cognitive deficits in offspring of parents with bipolar disorder.

Xiaoyue Li, Wenjin Zou, Robin Shao, Weicong Lu, Lishuo Chao, Xuanhao Zhao, Kuan-Pin Su, Kangguang Lin

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In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

8 authors.

Xiaoyue LiDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510145, Guangdong, P.R. China.

Wenjin ZouDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510145, Guangdong, P.R. China.

Robin ShaoDepartment of Psychology, The University of Hong Kong, Hong Kong 000000, P.R. China.ORCID https://orcid.org/0009-0003-5370-1599

Weicong LuDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510145, Guangdong, P.R. China.

Lishuo ChaoDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510145, Guangdong, P.R. China.

Xuanhao ZhaoDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510145, Guangdong, P.R. China.

Kuan-Pin SuDepartment of Psychiatry and Neuroscience, College of Medicine, China Medical University, Taichung 406040, Taiwan.

Kangguang LinDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510145, Guangdong, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation and white matter disruptions have been implicated in cognitive impairments associated with bipolar disorder, particularly in information processing speed (IPS). These neurological factors may manifest in at-risk offspring, even prior to the full development of the disorder, emphasizing the importance of investigating their role in early cognitive changes associated with bipolar disorder. This study examines these associations in offspring with varying levels of risk for bipolar disorder. Offspring of parents with bipolar disorder were classified as asymptomatic (AO,

Indexed as

bipolar disorderfamilial riskinformation processing speedneuroinflammationwhite matter

Identifiers

PMID42232610

DOI10.1093/braincomms/fcag181

PMCPMC13225265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.