ArticleERJ open research2026
The effect of high altitude on exercise capacity and cardiorespiratory function in patients with pulmonary vascular disease after an overnight stay at 2500 m: a randomised crossover study.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: We investigated the effect of an overnight stay at high altitude (HA; 2500 m) on constant work rate exercise test (CWRET) time and cardiorespiratory function in patients with pulmonary vascular disease (PVD) and the impact of supplemental oxygen therapy (SOT) in case of severe altitude-induced hypoxaemia. Methods: In a randomised crossover trial, stable patients diagnosed with pulmonary arterial or distal chronic thromboembolic pulmonary hypertension (PVD, PAH/CTEPH) performed a symptom-limited cycling CWRET at 470 m and after an overnight stay at 2500 m. For safety, patients with an oxygen saturation measured by pulse oximetry ( Results: Of 27 PVD patients (44% female; mean age 62±14 years, 20 PAH, seven distal CTEPH), 10 (37%) required SOT. Overall at HA Conclusion: The majority of PVD patients tolerated an overnight stay at 2500 m well. In those without need for SOT at HA, CWRET time was reduced with increased hypoxaemia and hyperventilation. In PVD patients who received SOT due to severe nocturnal hypoxaemia, SOT restored CWRET time to 470 m levels and dampened the exercise-induced hypoxaemia.
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