Evidence map›Paper›PMID 42232559›Full record

ArticleERJ open research2026

Blood proteomics of paediatric bronchiolitis obliterans syndrome after haematopoietic cell transplant.

Kasiani C Myers, Emily J Skala, Sudhir Ghandikota, Anil G Jegga, Nadeem Mousa, Matthew E Siefert, Adam Lane, Valentina Reffatto, Christopher Towe, Nathan Luebbering and 6 more

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Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kasiani C MyersDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Emily J SkalaDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Sudhir GhandikotaDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Anil G JeggaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nadeem MousaDepartment of Pediatrics, Valley Children's Hospital, Madera, CA, USA.ORCID https://orcid.org/0009-0006-2820-0241
Matthew E SiefertDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Adam LaneDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Valentina ReffattoDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Christopher ToweDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nathan LuebberingDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Sheyar AbdullahDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Azada IbrahminovaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Alexandra BridgelandDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Samuel GoldfarbDepartment of Pediatrics, School of Medicine at the University of Minnesota, Minneapolis, MN, USA.
Stella M DaviesDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Assem G ZiadyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The molecular determinants for lung graft- Methods: Participants included three cohorts: seven with BOS; seven sex-, age- and timepoint-matched with severe graft- Results: Our proteomic approach evaluated the expression of 190-12 588 protein isoforms, depending on statistical stringency, and distinguished the three cohorts of paediatric patients prior to and at the time of BOS diagnosis. Differences included proteins that regulate chromatin modification, acute phase signalling, complement, fibrosis, hypoxia, serine protease inhibition, vitamin transport, glucocorticoid receptor transactivation and blood coagulation pathways. A subset of newly discovered proteins was cross-platform validated by ELISA in a larger cohort of paediatric patients 14 (n=107), 30 (n=108), 60 (n=108) and 100 (n=134) days post-transplant. Pathways analysis highlighted potential therapeutics including azithromycin, statins, pazopanib and cediranib. Conclusion: Our strategy offers a potential for early diagnosis and the identification of interventions for paediatric stem cell transplant-associated graft-

Identifiers

PMID42232559
PMCPMC13224205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.