SynthesisFrontiers in oncology2026
Global research trends and hotspots of colorectal cancer organoids: a bibliometric insight and visualization analysis via multiple databases.
Synthesis in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Berberine restrains the expansion of colorectal cancer organoids by blocking cell cycle progression and reducing lipid synthesis.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Bibliometrics was adopted to analyze the research trends of colorectal cancer organoids, and to identify the global research hotspots and prospective directions. Methods: Publications related to colorectal cancer organoids published from January 1, 2010 to December 31, 2025 were obtained from the Web of Science Core Collection (WOSCC) and Scopus databases. Bibliometric and visualization analyses were conducted utilizing Bibliometrix R package, Python, CiteSpace and VOSviewer to explore the publication trends, countries, institutions, journals, authors and thematic evolution. Results: A total of 2239 relevant publications were included. The analysis revealed an explosive growth in the number of publications in this field over the past 16 years. China and the United States were the main contributors, and Utrecht University was the most productive institution. Hans Clevers had the highest total citations and number of publications, reflecting his leading influence in the field. Conclusion: Research on colorectal cancer organoids is shifting from the construction and optimization of conventional organoid models to the development of high-fidelity disease models. Current studies focus on the simulation of the tumor microenvironment and personalized cancer therapy, and colorectal cancer organoids will achieve broader clinical applications in precision oncology in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.