A case report of gastroduodenal intussusception caused by gastric gastrointestinal stromal tumor.

Introduction: Intussusception is most commonly seen in children and is relatively rare among adults. While it can occur anywhere in the gastrointestinal tract, gastroduodenal intussusception resulting from gastrointestinal stromal tumors (GIST) is a rare clinical finding. Case presentation: Here we report a case of gastroduodenal intussusception caused by gastric GIST in a 68-year-old female. She sought medical attention for symptoms including nausea, recurrent vomiting of blood, and epigastric pain. Plain computed tomography (CT) scan revealed a well-defined mass located on the gastric fundus, which was confirmed intraoperatively. Endoscopy demonstrated that the mass had prolapsed into the duodenum. Based on these findings, gastroduodenal intussusception secondary to a gastric tumor was diagnosed. The patient underwent successful partial gastric resection, which confirmed a mass originating from the gastric fundus and prolapsing into the duodenum. The postoperative pathological diagnosis was low-risk gastric GIST according to the National Institutes of Health (NIH) criteria. The patient was followed up for 12 months, undergoing CT imaging at 6 months and both CT and gastroscopy at 12 months, with no evidence of tumor recurrence. Conclusion: Gastric GISTs are a rare but clinically significant cause of adult gastroduodenal intussusception, typically necessitating surgical intervention. Multimodal imaging, particularly CT, plays a crucial role in preoperative diagnosis, while histopathological examination remains essential for definitive diagnosis and risk stratification. Treatment should be individualized based on tumor size, location, and patient factors.