Evidence map›Paper›PMID 42232508›Full record

ArticlebioRxiv : the preprint server for biology2026

Type 1-polarized DC immunotherapeutic contains heterogeneous populations with IL-12p70 production restricted to a rare subset.

Allison E DePuyt, Peter E J Shoucair, Holly Bilben, Jeremy J Martinson, Bernard J C Macatangay, Charles R Rinaldo, Pawel Kalinski, Robbie B Mailliard

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Allison E DePuytDepartment of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.ORCID 0000-0002-5572-858X
Peter E J ShoucairDepartment of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
Holly BilbenDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jeremy J MartinsonDepartment of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.ORCID 0000-0003-4673-7238
Bernard J C MacatangayDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-0405-0991
Charles R RinaldoDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-9194-3164
Pawel KalinskiDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-7025-3562
Robbie B MailliardDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-5501-503X

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Immaculate Lillian Nankya · 1994 to 2026
$50.0M
University of Pittsburgh MWCCS Clinical Research SiteU01HL146208 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bernard Jonas C Macatangay, CHARLES R RINALDO · 2019 to 2026
$32.2M
Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional CureU01AI131285 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MACATANGAY, BERNARD JONAS C, MELLORS, JOHN W · 2017 to 2021
$7.4M
Chemical Biology of HIV-1 NefR01AI152677 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas E. Smithgall · 2020 to 2026
$4.8M
Antigen-specific ‘kick and kill’ of the latent HIV reservoir using dendritic cellsR01AI152655 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robbie B Mailliard · 2022 to 2026
$3.2M
Illumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985k
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
NHLBI NIH HHS U01 HL146208NIAID NIH HHS P30 AI036219NIAID NIH HHS R01 AI152655NIAID NIH HHS R01 AI152677NIAID NIH HHS U01 AI131285NIH HHS P51 OD011132NIH HHS S10 OD026799NIH HHS S10 OD028483
6 · The paper itself

Abstract

Monocyte-derived DC therapies programmed for robust IL-12p70 production have been associated with favorable outcomes in cancer clinical trials. However, clinical responses remain inconsistent even under standardized protocols, and the cellular basis for this variability is unknown. We leveraged single-cell multiomics to characterize two widely used DC platforms, the high-IL-12p70-producing alpha-Type-1-polarized DC (αDC1) and the IL-12p70-deficient DC induced in the presence of PGE

Identifiers

PMID42232508
PMCPMC13225277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.