Evidence map›Paper›PMID 42232309›Full record

ArticleFrontiers in cardiovascular medicine2026

Longitudinal assessment of myocardial involvement in PASC-CVS: a single-center study from China based on multiparametric CMR.

Ai Shang, Shan Yang, Jiaye Tao, Jie Shen, Yi Zhan, Yinwen Gan, Zhiyong Zhang, Hang Jin, Fei Shan

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ai Shang *Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shan Yang *Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiaye Tao *Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jie ShenDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yi ZhanDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yinwen GanDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zhiyong ZhangDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Hang JinDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Fei ShanDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Persistent cardiac symptoms after COVID-19, termed post-acute sequelae of SARS-CoV-2 infection with cardiovascular involvement (PASC-CVS), remain poorly understood. This study aims to reveal myocardial involvement and long-term cardiac magnetic resonance (CMR) changes in PASC-CVS patients, providing insights into disease progression and recovery. Methods: This prospective single-center study in China enrolled 110 patients with PASC-CVS from March 2023 to April 2024. All participants underwent multiparametric CMR imaging to explore abnormal CMR manifestations in PASC-CVS patients. Clinical symptoms and CMR examinations were collected again one year later. Statistical analysis included the Wilcoxon signed-rank test and logistic regression. Results: Compared to controls, PASC-CVS patients exhibited significant differences in multiparametric CMR parameters, including Quantification of late gadolinium enhancement (LGE) (%) [odds ratio (OR): 6.36], Global extracellular volume (ECV) (ms) (OR: 1.33), Heart rate (bpm) (OR: 1.08), left ventricular global longitudinal strain (LV GLS) (%) (OR: 1.44), and Global native T1 (ms) (OR: 1.01). The combined multiparametric CMR parameters (Quantification of LGE, Global ECV, Heart rate, LV GLS, Global Post T1, and Global native T1) achieved an area under the curve (AUC) of 0.94, indicating excellent predictive value. At the one-year follow-up ( Conclusions: Our study reveals myocardial involvement in PASC-CVS patients, with follow-up improvements in RV EF and global T2, underscoring the utility of multiparametric CMR in monitoring and managing PASC-CVS.

Indexed as

cardiac magnetic resonance imaginglong coronavirus disease 2019longitudinal studymultiparametric imagingpost-acute sequelae of SARS-CoV-2 infection with cardiovascular involvement

Identifiers

PMID42232309
PMCPMC13223151

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