Evidence map›Paper›PMID 42232221›Full record

ArticleMolecular therapy. Advances2026

Efficient and safe lung gene delivery using AAV6.2FF in neonatal pigs demonstrates pediatric translational potential.

Nicole Zielinska, Erin L Howard, Cici Yang, Brenna A Y Stevens, Melanie M Goens, Yanlong Pei, Brad Thompson, Jeff L Caswell, Bernard Thebaud, Douglas Wey and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nicole ZielinskaDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Erin L HowardDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Cici YangDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Brenna A Y StevensDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Melanie M GoensDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Yanlong PeiDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Brad ThompsonAvamab Pharma Inc., Calgary, AB T2T 2P9, Canada.
Jeff L CaswellDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Bernard ThebaudOttawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada.
Douglas WeyDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Alexander ValverdeDepartment of Clinical Studies, Ontario Veterinary College, Guelph, ON N1G 2W1, Canada.
Luis G ArroyoDepartment of Clinical Studies, Ontario Veterinary College, Guelph, ON N1G 2W1, Canada.
Sarah K WoottonDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While adeno-associated virus (AAV) vectors have demonstrated efficacy in multiple organ systems, gene delivery to the lung remains an unmet therapeutic target. To treat a monogenic lung disease like surfactant protein B deficiency, a gene delivery system must overcome pulmonary barriers and be validated in models that closely resemble the human respiratory tract. Here, we optimized the endotracheal delivery of AAV6.2FF, an engineered capsid with enhanced pulmonary tropism, in neonatal piglets with lung features comparable to those of human newborns. We optimized delivery parameters that improved pulmonary distribution and applied them to administer AAV6.2FF expressing secreted alkaline phosphatase (SEAP) at two different doses: 5 × 10

Indexed as

AAVAAV6.2FFAAV vector biodistributionadeno-associated virusatomizerlung gene therapyneonatal pigssurfactant protein B deficiency

Identifiers

PMID42232221
PMCPMC13223870

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.