Evidence map›Paper›PMID 42232210›Full record

ArticleJournal of oral microbiology2026

Transient restructuring of the active oral resistome during probiotic

Nadeeka S Udawatte, Chun Liu, Reuben Staples, Pingping Han, Purnima S Kumar, Thiruma V Arumugam, Sašo Ivanovski, Chaminda Jayampath Seneviratne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nadeeka S UdawatteThe University of Queensland, School of Dentistry, Centre for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia.
Chun LiuThe University of Queensland, School of Dentistry, Centre for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia.
Reuben StaplesThe University of Queensland, School of Dentistry, Centre for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia.
Pingping HanThe University of Queensland, School of Dentistry, Centre for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia.
Purnima S KumarDepartment of Periodontics and Oral Medicine, School of Dentistry, The Ohio State University, Columbus, OH, USA.
Thiruma V ArumugamLa Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, QLD, Australia.
Sašo IvanovskiThe University of Queensland, School of Dentistry, Centre for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia.
Chaminda Jayampath SeneviratneThe University of Queensland, School of Dentistry, Centre for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia.ORCID https://orcid.org/0000-0003-0816-538X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The oral cavity harbours a complex and transcriptionally active antibiotic resistance gene (ARG) reservoir shaped by polymicrobial biofilm ecology. Whether probiotic-mediated ecological modulation can remodel the active resistome without promoting horizontal gene transfer remains poorly understood. Objective: To investigate the impact of Design: Saliva-derived polymicrobial biofilms were established on three-dimensional melt electrowritten poly(ε-caprolactone) (MEW-mPCL) scaffolds and exposed to Ssk12. Metatranscriptomic profiling was performed across four time points (Baseline, Day 4, Day 7, and Day 10), complemented by quantitative PCR validation and ARG-mobile genetic element (MGE) co-localisation analysis to characterise resistome restructuring during probiotic colonisation and decolonisation. Results: Baseline biofilms contained 27 ARGs spanning 16 antibiotic classes, predominantly Conclusions:

Indexed as

active resistome modulationantibiotic resistance genes (ARGs)metatranscriptomicsoral 3D MEW mPCL polymicrobial biofilm modeloral bacteriaoral probioticprobiotic colonizationStreptococcus salivarius K12

Identifiers

PMID42232210
PMCPMC13224720

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.