ArticlePain reports
Increasing age is associated with elevated circulating interleukin-6 and enhanced temporal summation of mechanical pain in people living with HIV and chronic pain.
Article in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- "Everybody looks at it as drug use instead of pain management": Experiences of chronic pain and its management among older people living with HIV who use drugs in Vancouver, British Columbia.Drug and alcohol dependence · 2024Article
- People living with HIV and the emerging field of chronic pain-what is known about epidemiology, etiology, and management.Current HIV/AIDS reports · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Introduction: In the current antiretroviral treatment era, people living with HIV (PLWH) can achieve a near-normal life expectancy. However, as PLWH grow older, they are increasingly prone to developing chronic health conditions including pain. One possible explanation for increased pain in older populations with HIV is that aging is associated with inflammation and altered pain modulatory processes (ie, increased facilitation and decreased inhibition). Objectives: Our study aimed to examine how age affects endogenous pain modulatory processes in PLWH with chronic pain and to examine how age affects serum inflammatory cytokines. Methods: A total of 80 PLWH (median CD4 Results: Mean age was 48.9 (8.2) years; range: 26 to 67, with 45% >50 years. In adjusted multiple regression models, increasing age was associated with elevated levels of circulating IL-6 ( Conclusion: Findings suggest that high levels of some circulating proinflammatory cytokines as well as enhanced pain facilitatory processes together may contribute to the chronic pain experienced by older adults with HIV.
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Registered trials
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