ArticleIBRO neuroscience reports2026
A refined porcine lumbar spinal cord injury model facilitating postoperative care.
Article in IBRO neuroscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pigs exhibit strong anatomical and neurological similarities to humans, making them valuable translational models for spinal cord injury (SCI) research. While most porcine SCI models target thoracic levels, these are often associated with significant postoperative management challenges, particularly related to urinary function. Methods: To address these limitations, we characterized a refined lumbar SCI model targeting the L3 vertebral level in pigs, based on comparative anatomy and veterinary data. SCI was induced using a contusion-compression paradigm under per-operative C-arm fluoroscopic guidance. Functional assessments were conducted at three time points: 2 days pre-injury, and 2 and 14 days post-injury. These included general activity monitoring, qualitative evaluation using the Porcine Thoracic Injury Behaviour Scale (PTIBS), and quantitative gait analysis using inertial measurement units and electro-goniometers. Animals were euthanized 3 weeks post-injury for Results: All animals developed complete paraplegia at 2 days post-injury (PTIBS = 1), progressing to severe but partial recovery by day 14, with a significant decrease in PTIBS score (-6.5 ± 0.3) and hip extension (-36.1%). Importantly, all animals exhibited immediate and persistent urinary incontinence, avoiding the need for catheterization. MRI and histological analyses confirmed consistent and reproducible lesions at the injury site, affecting both white and grey matter. Conclusions: This refined lumbar SCI model induces reproducible motor deficits associated with urinary incontinence, facilitating postoperative management while preserving translational relevance. It provides a practical platform for investigating functional recovery and testing therapeutic strategies in SCI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.